I set fatigue to 35 and play my starters 1 quarter in the 1st game then 2 quarters in games 2 and 3 then just 1 quarter if theres a game 4.
To me...this game is all about depth so you can fully rest injured players during the season.
I carry the following depth
QB 2
RB 4
FB 1
TE 2
WR 5
LT 3
LG 3
C 3
RG 3
RT 3
K 1
P 1
LDE 3
DT 4
RDE 3
SLB 3
MLB 4
WLB 3
CB 5
SS 2
FS 2
If you added it up....it equals 60 which means you need versatility from some players to fill different postions.
The best places to get versatility is WR that can play RB...Offensive lineman that can play multiple positions. Defensive lineman that can play inside and outside. Linebackers that can play inside or outside.