It depends on what position they play. I'll be more likely to chance a high volatility RB or defensive player. Even if their skills bust, they still have the speed/strength I'm looking for. I'm least likely to spend a high pick on a high volatility OL. Yes the physical attributes don't change, but I also want blocking skills on my OL. Nothing worse than a man mountain with no blocking skills.
High volatility QBs are next least likely, unless they have a lot of red already for pass accuracy and then WR, whom I like to be able to catch and run routes.